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Tumors have an abnormal rate of cell growth and cell division. Tumor cells release circulating tumor DNA (ctDNA),cellfreeDNA(cfDNA),mRNAand1microRNA,in the blood and body fluidswhich are 2the by-product of tumor cell lysis.Both ctDNA and cfDNA provide valuable information regarding the cancer related mutations, genetic aberrations and 3presence of cell free Nucleic acid (cfNA).The ctDNA provides information about the primary tumor and its secondaries / metastases. It is these ctDNA that anchor into novel locations and start dividing to 2develop secondaries of the tumours.Tumor biopsy is an invasive procedure in which tissue is excised from a growth and examined under a microscope. However, “Liquid Biopsy” is a relatively newer technique to find and evaluate cancer cells or their products in blood and body fluids that circulate after tumor cell lysis.
Prof. Dr. Rizwan Hashim. (2021) Liquid Biopsy: Opportunities and Expectations, Journal of Islamic International Medical College, Volume 16, issue 1.
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