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Background:Obesity is associated with inflammatory diseases and obese individual’s poses high risk for infections.Surfactant protein D (SP-D) is an importantregulator ofimmunity and inflammation. Latest studies have suggested that it is also involved in lipid homeostasis and obese subjects have decrease concentration of SP-D as compared to normal weight peoples. The aim of the current study was to elucidate the relationship among serum SP-D and BMI.Method: This cross sectional study wasperformed atDow University of health sciences (DUHS), Karachi.Weanalysed 90 obese and non-obese subjects for serum SP-D concentration. SP-D was estimated byELISA. Data was analysed by SPSS 16. Mean SP-D level and demographical variablesbetween the groups were compared by t test,Associations of SP-D with BMI investigated by regression analysis.Results:obese subjects have significant lower levels of Serum SP-D than non-obese and negatively associated with BMI in both genders (p=0.000).Conclusion: Thisstudy concluded that obese subjects have lower concentration of SP-D as compare to non-obese and there is an inverse association between the SP-D and BMI
Dr Shireen Jawed,House, Nighat Mannan, Masood Anwar Qureshi. (2016) ASSOCIATION OF SURFACTANT PROTEIN-D WITH OBESITY, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 28, Issue 3.
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