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OBJECTIVE: To determine demographic and clinico-pathological
characteristics of patients suffering from multiple myeloma (MM) in Peshawar,
Pakistan.
METHODS: This descriptive, retrospective study was conducted at Pathology
Department, Rehman Medical Institute, Peshawar, Pakistan from January 2006
to September 2018. Detailed information of forty patients diagnosed with MM
was collected. World Health Organization (WHO) set criterion was utilized to
diagnose MM. SPSS version 22 was used for Statistical analysis.
RESULTS: Out of 40 patients, 72.5% were males with male to female ratio of
2.63:1 and mean age of patients was 59.26±13.1 years. The common
presenting complaints were body/bony pain (87.5%), fatigue (72.5%), body
tenderness (45%) and backache (42.5%). Pallor was present in 33 (82.5%)
patients. Laboratory studies showed mean hemoglobin level of 8.6±2.1 g/dl,
anemia (92.5%), thrombocytopenia (27.5%) and hypercalcemia (17.5%).
Elevated ESR >100 was noted in 29 (72.5%) cases. Renal impairment was
established in 35% of patients. Urinary Bence Jones protein was present in 13
(32.5%). Serum protein electrophoresis showed M band in 39 (97.5%) cases.
Lytic lesions were detected in X-rays of 31 (77.5%) patients. Based on
international staging system, nine (22.5%) cases were in stage I, 16 (40%) in
stage II and 15 (37.5%) in stage III.
CONCLUSION: Majority of multiple myeloma patients in our study were in
th the 6 decade of life. Bone pain and fatigue were the most common presenting
symptoms. Anemia and elevated ESR were the most common laboratory
parameter. Most of the patients were diagnosed in later stages (stage II and III).
Shifa Basharat, Zufishan Batool, Nosheen Ali. (2019) CLINICAL PROFILE OF MULTIPLE MYELOMA IN A TERTIARY CARE HOSPITAL OF PESHAWAR, PAKISTAN, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 11, Issue 3.
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