• Ghulam Abbas Kandhro

• Tasneem Gul Kazi

• Sirajuddin

• Naveed Kazi

• Hassan Imran Afridi

• Mohammad Balal Arain

• Jameel Ahmed Baig

• Abdul Qadir Shah

• Nasreen Syed

تلخیص

The aim of present study was to evaluate the iodine/iodide status in biological samples (serum and urine) of 172 male hypothyroid patients (HPs) and their supplemental effects on thyroid hormones. For comparison purpose, non-goitrous subjects (n= 220) of same age group and socioeconomic status were also studied.A simple and rapid iodide-ion selective electrode (ISE) was used to measurethe concentration of iodine in microwave assisted acid digested serum and urine samples. Quality control for the methodology was established with certified samples and with those obtained by conventional wet acid digestion method on the same certified reference materials (CRMs) and real samples. A linear calibration curve was obtained for a reasonable concentration range of the potassium iodide solutions. The mean concentration of iodine in the serum and urine samples of theHPswassignificantly reduced as compared to control male subjects (p< 0.01). The low levels offree triiodothyronine and thyroxin were found in HPs than age matched healthy control (p< 0.005 and 0.002) respectively whilehigh levels of thyroid stimulating hormone were observed in HPs (p< 0.008). The proposed method was relatively efficient as well as cost effective by using inexpensive equipment. It was observed that iodine in biological samples of HPs can play an important role in determining the severity of the hypothyroidism

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