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The toxic effects of a toxicant result in histo-pathological and hematological variations that may lead to
hepatic inflammation. Plant extracts and essential oils have long been used in medicines and food additives despite of their detrimental effects. Eucalyptus oil (EO) is commonly used in pharmaceutical industry for its high
contents of menthol. The current study was planned to study the hepatotoxicity and hemotoxicity in Wistar rats. A
dose dependent study was executed with T1= 1.25ml/kg, T2 = 2.5ml/kg and T3 = 5ml/kg (kg of body weight) of
oral administration of EO. The three experimental groups were compared with control. The animals were dissected and blood extracted by direct heart puncture. Liver was excised and formalin fixed for H&E staining.
A statistically significant increase was observed in MCV, percentage RDW and HCT that arguments for macrocytic anemia. With conserved morphology, the hepatic lobules have shown recruitment of inflammatory cells in
perivascular areas with lower degree of hepatocytic necrosis.
Taken together these results we can conclude that EO can cause sterile inflammation to the liver with macrocytic
anemia
NADEEM SHEIKH, MOHSIN SHAFIQ, NIDA ZIA. (2016) Macrocytic Anemia and Liver Inflammation Induced by Eucalyptus Oil, Biologia – Journal of Biological Society of Pakistan, Volume 62 (I), Issue 1.
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