Abstract
One of the major causes of surgical site infection (SSI) is an inappropriate surgical site preparation
that leads to postoperative complications. Although preoperative skin preparation is a standard surgical
practice to prevent SSI, the choice of skin disinfectants and methods of skin preparation is still aberrant in
veterinary practice. The study was, thus, conducted to standardize pre-surgical skin preparation with various
formulations of Chlorhexidine gluconate, Chlorxylenol, and Povidone-iodine (PI) in goat. Seven surgical
fields were prepared for evaluating seven formulations of these antiseptics. The bacterial swabs collected at
different stages of skin preparations were transferred in nutrient broth and cultured in Plate Count Agar for
counting of Colony Forming Unit (CFU). Results revealed that Chlorxylenol was less efficacious than PI and
Chlorhexidine gluconate when mean CFU was counted at different stages of surgical field preparation. Soap
water scrubbing and ethanol spray followed by aqueous Chlorhexidine gluconate painting eliminated 100%
bacterial load and kept the site aseptic for 60 min. On the other hand, alcoholic Chlorhexidine gluconate
completely removed bacterial burden from the skin and maintained 90 min long aseptic condition of the
operation site. Based on our findings, alcoholic Chlorhexidine gluconate was the best in producing an aseptic
surgical field for a longer duration. Our findings recommend robust scrubbing of the surgical site with
detergent or soap water followed by 70% ethanol or hexisol spray and then painting the site with antiseptic
preferably with alcoholic Chlorhexidine gluconate solution to generate aseptic surgical site which is very basic
to prevent SSI and postoperative complications
Md. Al-Amin Tan, Mst. Antora Akter, Md. Sabuj Rahman, Marzia Rahman, Md. Mahmudul Alam, Md. Mahmudul Alam. (2020) Standardization of Surgical Site Preparation with Different Formulations of Povidone-Iodine, Chlorhexidine-Gluconate and Chlorxylenol in Caprine Model: A Comparative Study, Journal of Innovative Sciences, Volume 6, Issue 1.
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