Abstract
Cardiovascular diseases are the leading cause of death along the world about 30% of all deaths
occur due to cardiovascular diseases. Among fibrinolytic enzymes streptokinase (SK) is commonly used in
the world to cure heart diseases because its low cost and efficacy. It’s a microbial origin enzyme produced
especially by Streptococcus bacterial spp. Therefore, it is antigenic in nature due to microbial source which
restricts its use. However, it is necessary to truncate antigenic regions present in the SK gene for the removal
of streptokinase antigenicity. The basic goal of this research work is to highlight antigenic regions founded in
streptokinase molecule and to give strategy to remove these antigenic sites
Ghulam Akbar, Muhammad Anjum Zia, Ali Ahmad, Neha Arooj, Shahneela Nusrat. (2020) Review on Streptokinase with its Antigenic Determinants and Perspectives to Develop its Recombinant Enzyme with Minimum Immunogenicity, Journal of Innovative Sciences, Volume 6, Issue 1.
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