Abstract
espite many organized health initiatives and critically acclaimed guidelines for proper management of
asthma therapy, there is still a large population of severe asthmatics having an uncontrolled disease.
Severe persistent asthma, characterized by chronic airway inflammation, increased eosinophils and
serum IgE is currently managed by using inhaled corticosteroids. It is quite challenging to get the best treatment
guidelines for bronchial asthma in severe asthmatics, particularly in the presence of steroid resistance and the
non-responsiveness to β-agonists. For that purpose, other methodologies are required to reverse the
uncontrolled airway remodeling in steroid-resistant severe asthma. These advanced alternative approaches
should be able to treat asthma symptoms and to improve the inflammatory conditions underlying characteristic
pathological features of asthma. The current review focuses and summarizes the alternative approaches used
in severe asthma patients. Agents targeting inflammatory cytokines, phosphodiesterase inhibitors, antibodies,
oligonucleotides, stem cells, and target drug delivery using gene silencing, offer promise in treating severe
asthma.
D
Sibtain Afzal, Khushnooda Ramzan, Ahmed Bilal Waqar. (2019) Alternative approaches for the treatment of Asthma and COPD: Focus on Cell-based therapies, Epigenetics, and Gene silencing approaches, Advancements in Life Sciences, Volume 7, Issue 3.
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