Abstract
Objective: To evaluate the spectrum of morphological changes seen on histological examination of Erythema multiforme in
a local population.
Material and methods: This descriptive study was conducted at Pathology Department of Pakistan Institute of Medical Sciences, Islamabad from January 2015 to January 2018. Out of 44 cases diagnosed with Erythema multiforme, 34 cases were
included in the study according to inclusion/exclusion criteria. The cases having history of history of Stevens-Johnson syndrome and toxic epidermal necrolysis were excluded from the study. The microscpic features including epidermal changes
and dermal changes were studied and recorded. All data was entered into SPSS version 24. Frequencies of various histopathological changes were calculated.
Results: The common histological feature shown in all 34 cases (100%) was perivascular inflammation, while the least common features were scab formation and ulceration (17.6% each). 2nd highest histological feature was hyperkeratosis and
granulation tissue each (94.1%). There were 12 (35%) males and 22 (65%) females. The range of age in the present study
was between 11 and 70 years. Eight (23.5%) patients were in the age group of 11 to 19 years and 22 (64.7%) were in the
age range group of 40 to 70 years.
Conclusion: Microscopic features are varied but distinct which help in arriving at an accurate diagnosis of Erythema Multiforme. The most common histological feature is perivascular inflammation with interface inflammatory infiltrate. Other features include hyperkeratosis, granulation tissue formation, mucinous degeneration and acanthosis.
Pordil Khan, Muhammad Mudassar, Farhan Abbas Baloch, Muhammad Waqas, Aurangzeb Khan. (2020) SPECTRUM OF MORPHOLOGICAL CHANGES IN ERYTHEMA MULTIFORME, Journal of Medical Sciences, Volume 28, Issue 3.
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