Abstract
Objective: To assess the efficacy and safety of 0.1% tazarotene gel in treatment of mild to moderate acne vulgaris.
Methodology: This randomized controlled trial was conducted in Dermatology unit, MTI Lady Reading Hospital (LRH), Peshawar from June to December
2019. Total 90 patients with mild to moderate acne vulgaris were included in
the study. Patients were divided into three groups by lottery method. Group
A patients received topical 0.1% tazarotene gel in morning and evening application. Group B patients received topical vehicle (plain gel) in morning and
0.1% tazarotene gel in evening while group C received vehicle (plain gel) in
both morning and evening. Data was recorded in pre-designed proforma.
The one-way analysis of variance (ANOVA) was used to determine statistical
significance.
Results: In group A, 19 patients showed 61-95 % decrease while 11 patients
showed complete clearance of lesions after treatment with tazarotene gel
for 12 weeks. In group B, 17 patients showed 61-95% decrease, 8 patients
showed 41-60% decrease while 5 patients showed complete clearance of
acne lesions. In group C, 22 patients showed less than 10% while 8 patients
showed 10-20% decrease in the number of lesions. The difference was found
significant with p-value of 0.000 between three groups in terms of reduction
in the number of lesions at 12 weeks of treatment. Erythema, burning, peeling
and itching were the main side effects
Conclusion: Short term topical application of 0.1% tazarotene gel is safe and
effective for the treatment of acne vulgaris.
Mohammad Majid Paracha, Irfan Ullah, Kashif Kammal, Hina Zahoor. (2020) EFFICACY AND SAFETY OF SHORT TERM USE OF 0.1% TAZAROTENE GEL IN THE TREATMENT OF MILD TO MODERATE ACNE VULGARIS: A RANDOMIZED-VEHICLE CONTROLLED TRIAL, Journal of Postgraduate Medical Institute, Volume 4, Issue 2.
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