Abstract
Objective: To determine the frequency of Salmonella typhi and Salmonella Paratyphi A causing enteric fever among children and
recent trends of antimicrobial resistance among S.typhi and Paratyphi A to selected antibiotics.
Study Design: Cross sectional observational study
Place and Duration: At Department of Pathology Zubaida Medical Centre, Karachi from January 25th 2017 till 15th June 2018
Methodology: Positive blood samples of Salmonella were inoculated in Brain heart infusion broth and Blood and MacConkey agar for
subculture. Age, gender, Salmonella serovar and resistance pattern to seven antibiotics were recorded. Salmonella typhi and
Salmonella Paratyphi A were confirmed by using agglutinin serum against O and H antigens. Antimicrobial susceptibility was performed
by Kirby- Bauer disk diffusion method
Results: Out of 125 positive blood cultures, 49% Salmonella serovars were isolated. Salmonella typhi (86%) was the most frequent
organism isolated and 73.6% resistant Salmonella strains to different antibiotics were found. Overall resistance for both Salmonella
typhi and Salmonella Paratyphi A was observed 64% from ampicillin, 63% from chloramphenicol 39% from ciprofloxacin and 28% from
third generation ceftriaxone and cefixime.
Conclusion: The resistance to third generation cephalosporins among Salmonella typhi is considerably high. .
Mehveen Iqbal, Sabiha Mirza , Muhammad Akbar Hassan, Saira Bugti. (2019) Prevalence and current trends of antimicrobial resistance among Salmonella Typhi and Salmonella Paratyphi A in children, Isra Medical Journal, Volume 11, Issue 1.
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