Abstract
Objective: To evaluate the antioxidant effects of walnuts on raised levels of Malondialdehyde (MDA) by lead toxicity.
Study Design: Quasi Experimental study
Place and Duration: Department of Biochemistry, ANMCH, Islamabad, Pakistan in collaboration with National Institute of Health
Islamabad. The duration of the study was six months from November, 2015 to April, 2016
Methodology: A total of 60 BALB/c mice were divided into three groups of 20 mice each. Group was given normal standard diet.
Group was given lead acetate in drinking water with normal diet without any supplementation. Group was given lead acetate
with diet supplemented with walnuts. Levels of malondialdehyde were measured by using Thiobarbituric acid reactive substances
(TBARS) method at the end of study.
Results: The data obtained from this study indicates that lead caused increase in serum Malondialdehyde (38.06±2.99.) levels in group
. Supplementation of walnut along with lead showed decrease in serum malondialdehyde levels (7.91±2.23) in group as compared
to group .
Conclusion: Walnuts are rich in antioxidants and prevent against the lead induced oxidative stress by decreasing serum
Malondialdehyde levels
Roomisa Anis, Muhammad Waseem Kausar, Naveeda Zaigham, Muhammad Burhan Ul Haq, Sobia Humerah, Beenish Zafar. (2019) Antioxidant effects of walnuts on malondialdehyde levels raised by lead toxicity in mice, Isra Medical Journal, Volume 11, issue 6.
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