Abstract
Objective: To identify the bacteriological profile of bloodstream infections and their antibiotic susceptibility pattern.
Study Design: Descriptive observational study (Retrospective study).
Place and Duration: Microbiology section, Dow University of Health Sciences from 2nd January, 2010 to 3rd January, 2015.
Methodology: Blood culture reports were screened for the presence of bacterial growth. Then Frequency of different bacterial
isolates along with their antibiotic resistance pattern was noted and analyzed.
Results: During the study period, 13544 blood cultures were analyzed of which 18% were positive for growth. Among those 97%
were bacterial isolates and only 2% were candida species. Among the Gram positive isolates, Coagulase negative Staphylococcus
(20%) and Staphylococcus aureus (14%) were the commonest. Among the Gram-negative isolates, Salmonella species (18%)
followed by Klebsiella species (15.7%) and E.coli (12.9%) and Pseudomonas species (7%). Staphylococcus aureus was found highly
resistant to penicillin (95%), followed by erythromycin (68%), Co-trimoxazole (56%), Fusidic acid (54%) and Oxacillin
(48%).Resistance was found to be on lower side against ciprofloxacin (38%), gentamicin (21%), chloramphenicol (13%) and Amikacin
(6%).All isolates were sensitive to Linezolid. Salmonella species was resistant to ampicillin (54%) followed by Ciprofloxacin (44%), Cotrimoxazole (44%) and Chloramphenicol (44%).
Conclusion: Both Gram positive and Gram negative bacteria were responsible for blood stream infection. Piperacillin/Tazobactam,
Meropenem and Amikacin were the most effective antibiotics against Gram negative bacteria while vancomycin and linezolid was
most sensitive antibiotic against Gram positive bacteria.
Fatima Fasih, Samina Baig, Sambreen Zameer, Saima Naseem, Shaheen Sharafat. (2019) Bacteriological profile and drug resistance patterns of blood culture Isolates: A five year audit from tertiary care hospital., Isra Medical Journal, Volume 11, issue 6.
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