Abstract
Objective: To evaluate the synthesis of anti-Hbs in response to the Hepatitis-B vaccination in patients with Hepatitis C infection in
comparison with healthy people.
Study Design: Interventional Study.
Place and Duration: Department of Medicine and Department of Gastroenterology, Nishtar Hospital, Multan, from May 20, 2016 to
June 15, 2018.
Methodology: A total of 83 subjects were enrolled, 41 were patients of Hepatitis C infection (HCV) and 42 were normal healthy
individuals. Baseline anti-Hbs was done before vaccination. All the enrolled subjects (healthy and HCV patients) were administered
Hepatitis-B vaccine intramuscularly according to recommended schedule of 0, 1 and 6 months. Anti-Hbs were measured after one
month of third injection.
Results: Sero-protective representation was almost equal (more than 90%) for both groups (i.e. HCV patients and healthy
individuals). Males were more sero-protected than females for both HCV patients and healthy individuals. The representation of
sero-protection for males in HCV patients and healthy individuals were 56.09 % and 50.00 % respectively while the representation of
sero-protection for females were 36.58 % in HCV patients and 47.61 % in healthy individuals.
Conclusion: The standard dosage of hepatitis B vaccine gave sero-protective levels in both groups i.e. normal healthy individuals and
HCV patients. The antibody titers were almost equal in both groups as HCV infection has little or no effect on immune response of
body.
Muhammad Waseem Abbas, Rukhsar Javaid, Muhammad Nouman Iqbal, Muhammad Arslan Iqbal. (2019) Assessment of immunological response of Hepatitis B vaccination in patients of Chronic Hepatitis C (HCV), Isra Medical Journal, Volume 11, Issue 5.
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