Abstract
Objective: To evaluate biomarkers of insulin
resistance and acute phase reactants in obese,
overweight and lean subjects and investigate the
associations among those biomarkers
Methodology:This cross sectional study included
158 subjects who were stratified into three groups.
Group1 comprised 53 obese patients (BMI≥ 30
2
kg/m ); group 2 were 54 overweight subjects, and
2
group 3 had 51 healthy lean (BMI <25 kg/m ).
Insulin resistance biomarker was assessed by
Homeostatic Model Assessment of Insulin
Resistance (HOMA-IR) and Triglyceride to
Glucose (TyG) index. High-sensitivity C-reactive
protein (hsCRP), ceruloplasmin (CP), haptoglobin
(HP) and albumin were also evaluated as acute
phase reactants (APRs).
Results: HOMA-IR and TyG index, hs-CRP, CP,
HP and BMI were significantly increased in both
group1 and 2 as compared to lean Subjects
(p<0.01). Albumin levels were lower in
group1versus group 2 and group 3, respectively
(p>0.05). The TyG index and HOMA-IR showed
significant positive correlations with waist
circumference (WC), waist to hip ratio (WHR),
BMI, HP, CP, (p<0.001), and negative correlation
with albumin (p<0.01). Multiple regression
analysis showed that hsCRP and CP were the
most powerful predictors of insulin resistance in
obese and overweight subject as compared to
other APRs in this study. Additionally, WHR and
BMI are strong independent risk factors for insulin
resistance in these subjects.
Conclusion: Insulin resistance biomarkers
HOMA-IR and TyG index were linked with acute
phase reactants and obesity indices. (Rawal Med
J 202;45:513-518).
