Results: The mean age of the patients was
35.97±8.28 years. Efficacy was significantly
higher in group B as compared to group A
(p=0.020).
Methodology: This descriptive comparative study
was conducted from June 2018 to February 2019
at Department of Plastic & Reconstructive
Surgery, Dow University of Health Sciences and
Dr. Ruth KM Pfau Civil Hospital, Karachi. Total 60
patients with keloid at different body part were
randomly allocated into two groups. Group A was
given 50mg/ml 5-FU intra-lesion while in Group B;
in addition to 5-FU 50mg/ml (0.9 ml), 40 mg/ml
triamcinolone acetonide (0.1 ml) was given
intralesionally. The duration of treatment was 6
months during which injections were given at
weekly intervals for four weeks, then twice a month
for two months and then once a month until the
keloid lesions in both groups assumed virtually the
same level as that of surrounding tissue or for a
maximum of 3 months.
Objective: To compare the effectiveness of
intralesional 5-fluorouracil (5-FU) alone and in
combination with triamcinolone acetonide (TAC)
for treating keloids.
Conclusion: Patients who received intra-lesion 5-
fluorouracil (5-FU) in combination with
triamcinolone acetonide (TAC) showed better
results in treatment of keloid as compared to 5- FU
alone. (Rawal Med J 202;45:549-553).
