Methodology: This case control study was
conducted in Physiology Department of Basic
Medical Sciences Institute, Karachi, from 2013 to
April 2015 with the association of National Institute
of Child Health (NICH). It included 170 children of
age between 6-14 years of both gender. All
subjects were equally grouped into controls and
cases. Controls were recruited from school and
diagnosed cases of asthma were selected from
NICH as per Global Initiative for Asthma Guideline.
Serum vitamin D was estimated by ELISA kit.
Asthma was assessed by spirometry. Data were
analyzes by SPSS version 21.
Objective: To assess and compare serum
vitamin D in pediatric asthmatic patients with nonasthmatic healthy children to observe its role in the
progression of asthma
Results: Vitamin D in controls was 17.91
±0.48ng/ml and in cases was 15.18±0.21ng/ml
(p<0.001). Serum levels of mild and moderate
asthmatics with insufficient vitamin D were 16.5±
0.24ng/ml and 14.31±0.41ng/ml respectively and
deficient vitamin D of both groups were 7.3±
0.15ng/ml and 6.8± 0.44ng/ml respectively.
Significant indirect association was found
between vitamin D and age (r = -0.326, p=0.01).
v i t a m i n D w a s d i r e c t l y r e l a t e d w i t h
FEV1(r=0.274.p= 0.04).
Conclusion: In asthma, serum insufficient or
deficient vitamin D levels result in increased
inflammatory state of airways, which may impair
the natural immune defense system of lungs.
(Rawal Med J 202;45:607-610).
Afshan Mehboob Khan, Shahjabeen Khan, Darakhshan M Saleem, Fearoz Khan, Uzair Abbas, Shahneela Siraj. (2020) Serum vitamin D status in children of bronchial asthma, , Volume 45, Issue 3.
