Objective: To determine the frequency of
hypocitraturia in the treated patient of urolithiasis
in Karachi, Pakistan.
Methodology: This is a cross sectional study was
conducted in department of urology at Jinnah
Postgraduate Medical Centre Karachi from
January to December 2018 for a period of one
year. It included 170 patients who had been
treated for stone disease and were stone free at
the time of study. We measured 24 hours urinary
excretion of citrate by enzymatic citrate lyase
analysis (Bergmeyer method).
Conclusion: Hypocitraturia is the most common
metabolic disorder and an important risk factor in
stone formation particularly in calcium stones.
Dietary modifications should also be used in
conjunction with medical therapy. (Rawal Med J
202;45:626-628).
Results: Out of 170 patients, 115 (67.65%) were
male while 55(32.35%) were female. Mean age
was 39.34±11.87 years. Average urinary citrate
level was 262±199 mg/day. Hypocitraturia turned
out to be <320mg/day in 119(70%) patients and 51
(30%) patients had normal urinary citrate levels.
Hypocitraturia was more in patients with stone size
more than 2 cm and disease duration greater than
2 months with significant difference (p=0.001 and
p=0.012, respectively).
Suhail Dilawar Arain, Arif Ali Shaikh, Saeed Ahmed Khan, Mumtaz Ali Chandio. (2020) Hypocitraturia in the treated patients of urolithiasis, , Volume 45, Issue 3.
