Abstract
Methodology: Rodents were segregated into
Control group (I), Isoniazid group (II), Garlic group
(III) & Cassia Fistula group (IV). The control group
received only standard diet. The Group II received
standard diet along with anti-tuberculous drug.
The Group III and IV received standard diet along
with INH in addition to Cassia Fistula and Garlic.
Blood samples were collected after 1 week of
acclimatization and at 30th day.
Objective: To comparison of Cassia fistula leaves
and Garlic in preventing drug induced liver injury in
rats.
Conclusion: Toxic dose of INH caused severe
liver injury in group II, while liver injury was
prevented in group III and IV receiving CF and
Garlic, thus providing hepato-protective effect.
(Rawal Med J 202;45:725-727).
Results: In group II, elevated serum alanine fistula.
transaminase (ALT), aspartate transaminase
(AST), alkaline phosphatase (ALP) and total
bilirubin levels were noted. Group III showed
values close to normal levels of of liver function,
but Group IV showed values within range of
normal levels of biochemical indicators of liver
function
