Abstract
Objective: This present study is design to assess the efficacy and frequency
of side effects with a newer anti-epileptic agent levertiracetum while comparing an older antiepileptic, Sodium Valproate, in the patients with generalized tonic colonic epilepsy. Material &
Methods: Patients with GTC epilepsy had been allocated in two groups, A and B, Group A was
given Sodium valproate while group B was given levertiracetum. Study Design: Randomized
Control Trial. Setting: Fatima Memorial Hospital, Lahore and Allied Hospital, Faisalabad. Period:
December, 2017 to December, 2018. Results: Seventy five subjects were taking levertiracetum
from three months out of which 56(74.7%)were seizures free, 15(20%) were seizure free on
higher dose,6(8%) were with dizziness ,vertigo and 9(12%) were with somnolence. Fifty-four
individuals were seizures free with normal dose of sodium valproate from last 3 months, and
16(21%) were seizures free on higher doses among which 53(70%) were with side effects of
weight gain and 69(92%) were with hand tremors and this was the most prominent side effects
among individuals who were taking sodium valproate. Conclusion: Generalized tonic colonic
epilepsy is one of the most common forms of epilepsy and with the advent of newer antiepileptic drugs like levertiracetum, such seizures can be controlled in with lesser side effects as
compared to older antiepileptic agent Sodium Valproate.
Fahad Farooq, Gurdeep Singh, Farooq Ahmad, Faizan Farooq, Faiq Farooq, Kashif Saleem Khurram, Faisel Younas, Mimpal Singh. (2020) KEPPRA (Levetiracetum) VS EPIVAL (Sodium Valporate) to control generalized tonic clonic seizures., The Professional Medical Journal, Volume 27, Issue 12.
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