Abstract
Objectives: To provide awareness to the pathologists and technologists all about
the red cells parameters in cold antibodies concerned cases. Case Report Findings: A sixty
seven-years-old male admitted in emergency department of our hospital, having clinical history
of swelling and pain in both the lower limb and feet, on physical examination, provisionally
diagnosed as a case of Cellulitis and deep vein thrombosis(DVT). Blood specimen was obtained
for general hematological investigations. Full blood count (FBC) was performed on sysmex XP100 hematological analyzer which showed invalid findings especially red cells indices which
were not corresponding to the hemoglobin (Hb) concentration of the patient. Blood sample
was repeated, to confirm invalid red cells indices which showed values as in the 1st blood
specimen. Blood smears revealed aggregation of red cells. By warming the ethylenediamine
tetra-acetic acid (EDTA) tube containing the blood specimen, in water bath at 37⁰C for one hour
and repeated the FBC on hematological analyzer and found the corrected red cells indices.
Conclusion: Basic knowledge of cold antibodies and warming the blood sample at 37⁰c for
one hour helps the correct diagnosis.
Faiz Ahmed Faiz, Muhammad Faisal Bashir, Sidra Ghazanfer, Muhammad Fahad Faiz, Muhammad Tayyab, Khalid Aftab , Muhammad Tahir , Imran Idrees. (2020) Cold antibodies association with cellulitis, deep vein thrombosis and abnormal red cells indices: A Case Report., The Professional Medical Journal, Volume 27, Issue 12.
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