Milk production traits have been focus of livestock breeders and animal geneticist for the selection of dairy animals with
superior phenotypic and genotypic tendencies. Oxidized low density lipoprotein receptor 1 (OLR1) has been found controlling
high milk fat content in dairy cattle of many regions but no association has been reported in buffaloes so far. Buffalo being an
efficient converter of poor quality roughages into valuable products as milk and meat is known as black gold of Asia. Present
research was conducted for genetic exploration of OLR1 gene in river buffalo breed of Pakistan (Nili-Ravi). Animals were
categorized in high and low milk fat content (threshold ~ 8% milk fats). Genetic analysis revealed a total of fifteen variations
in the sequences of OLR1 gene. Chi square test revealed only one variation obeying hardy Weinberg equilibrium. This novel
mutation (P17H) was further analyzed by genotyping using AluI restriction enzyme. AA genotype of this variation was
associated with high milk fat content (8.86%). Results of this study illustrated the significance of this marker as selection
signature in our quest for genetically superior dairy buffaloes to enhance production potential of our animals.
Maryam Javed, Asif Nadeem, Masroor Ellahi Babar, Wasim Shehzad, Abu Saeed Hashmi. (2018) NOVEL POLYMORPHISM IN OLR1 GENE IS ASSOCIATED WITH HIGH MILK FAT CONTENT IN RIVER BUFFALO, , Volume 55, Issue 2.
