Abstract
Objective: To determine the association of Glycated Hemoglobin with frontal lobe cognitive dysfunction in type
1 diabetes patients.
Study Design: Case control study.
Place and Duration of Study: Bahawal Victoria Hospital, Bahawalpur, Pakistan from June 2016 until August
2017.
Materials and Methods: Fifty diabetic patients and fifty healthy adults were tested for fasting HbA levels. 1c
Following, they were administered Frontal assessment battery. Participants were given separate instructions
for assessment of each frontal lobe function and they completed Frontal assessment battery in a single testing
session. Data was analyzed for group differences on each frontal lobe function through ANOVA. Bivariate
correlations were computed to assess the relationship between frontal lobe functions and HbA Regression 1c.
analysis was used to assess HbA as a predictor of frontal lobe cognitive functioning 1c .
Results: Diabetic patients showed impaired performance on frontal lobe cognitive functions in contrast with
healthy individuals. HbA and frontal lobe cognitive functions were negatively correlated. Deficient glycemic 1c
control was associated with frontal lobe cognitive deficits. HbA was found as a significant predictor of frontal 1c
lobe cognitive functioning.
Conclusion: Higher level of HbA is a predictor of frontal lobe cognitive functioning deficits in patients with 1c
Type 1 diabetes.
Amara Gul, Memoona Sehar. (2019) Glycated Hemoglobin: A Predictor of Cognitive Deficits in Type 1 Diabetes Patients, Journal of Islamic International Medical College, Volume-14, Issue-2.
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