Abstract
Objective: To investigate and compare the antidiabetic effect of withania coagulans and Liraglutide on serum
postprandial insulin levels in streptozotocin induced diabetes in rats.
Study Design: Randomized Control Trial.
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Place and Duration of Study: The study was conducted from 1 April 2016 to 31 March 2017 at Islamic
International Medical College in collaboration with National Institute of Health Islamabad.
Materials and Methods: Total 40 male Sprague dawley rats were randomly divided into two groups; Group A
(n=10) and Experimental Group (n=30). Group A was given normal diet for 5 days whereas experimental group
was given normal diet plus streptozotocin (30mg/kg/day) intraperitoneally for 5 days and diabetes was
confirmed in experimental group by fasting blood glucose (mg/dl). Experimental group was further divided into
B (Diabetic control), C (Withania coagulans treated) and D (Liraglutide treated). First sampling group A and B
was done after 5 days. Group C were given Withania coagulans and Group D were given Liraglutide along with
normal diet for 30 days. Second sampling (fasting blood glucose, postprandial glucose and insulin level) was
done from group C and D.
Results: Fasting blood glucose of group C (98 mg/dl ± 1.80) was significantly reduced than group D (102 mg/dl ±
2.04). Postprandial glucose and insulin levels of Group D (163 mg/dl ± 3.95 and 6.06 μU/ml ±0.17) were
significantly decreased and increased as compared to Group C PPG (183 mg/dl ± 6.30) and insulin level (5.54
μU/ml ± 0.23).
Conclusion: Withania Coagulans significantly improves postprandial insulin levels as compared to liraglutide
Abdul Samad, Shazia Ali, Noman Sadiq. (2018) Comparison of Postprandial Insulin Levels in Withania Coagulans and Liraglutide Treated Diabetic Rats, Journal of Islamic International Medical College, Volume-13, Issue-4.
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