Abstract
Objective: To measure the serum levels of homocysteine and lipid profile in patients of subclinical
hypothyroidism.
Study Design:A case control observational study.
Place and Duration of Study: The Study was conducted in Biochemistry Department of Islamic International
Medical College, Rawalpindi during a period of one year from March 2016 to February 2017.
Materials and Methods: A total of 128 subjects were selected for the study from the medical outpatient
department using convenient non probability sampling technique. Selection criterion was age group of 20 to 55
years and exclusion criteria were history of diabetes, hypertension, cardiovascular or renal disease. Selected
patients were divided into two groups. In group I (selected as control) were sixty four healthy volunteers who
presented for routine annual medical and physical examination. In group II (patient's group) were 64 patients
diagnosed as subclinical hypothyroidism based upon thyroid stimulating hormone (TSH) levels >4.12 mU/mL
and normal free T3 (FT3) and T4 (FT4) levels on two consecutive measurements.Lipid profile and homocysteine
levels in the serum of the subjects of both groups were estimated. The collected data was entered in SPSS
version 21 for analysis. Descriptive data were given as mean ± standard deviation (SD). Independent t test was
used and p values less than 0.05 were considered statistically significant.
Results: Group I (control) consisted of 82.81% females and 17.18% males. In group II (sub clinical hypothyroid
patients) were 87.5% females and 12.5% males. The mean ages of controls and subclinical hypothyroid patients
were 33.65±5.98 and 35.20±7.55 years respectively. There was a significant increase in mean tHcy in subclinical
hypothyroid patients than in control group (Mean ± SD, 12.67±2.35 μmol /l vs 3.76±1.59 μmol/l). Serum total
cholesterol in subclinical hypothyroid patients was significantly increased than the control group (Mean ± SD,
195.25 ± 10.63 mg/dl vs 162.05 ± 17.39 mg/dl). There was a significant decrease in mean HDL-Cholesterol in
subclinical hypothyroid patients than in control group (Mean ± SD, 48.11 ± 4.62 mg/dl vs 53.85 ± 6.55 mg/dl).
There was a decrease in mean serum triglyceride in hypothyroid patients than in control group which was not
statistically significant (Mean ± SD, 111.25 ± 18.82 mg/dl vs 140.29 ± 17.69 mg/dl).
Conclusion: It was found in our study that the serum levels of homocysteine and lipid profile are increased in
subclinical hypothyroidism.
Aqsa Malik, Amina Rahim, Yasir Iqbal, Abdul Khaliq Naveed. (2017) Levels of Homocysteine and Lipid Profile in Subclinical Hypoth1 yroidism, Journal of Islamic International Medical College, Volume-12, Issue-4.
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