Abstract
Objective: The objective of the study was to observe and compare the changes in buccal exfoliated cells between smokers
and Nonsmokers.
Study Design: Cross sectional comparative study.
Place and Duration of Study: Study was carried out at Islamic International Dental College, Islamabad and Post Graduate
Medical Institute, Lahore. The duration of study was six months i.e 1st September 2013-lst March 2014.
Materials and Methods: Convinient, non-probability sampling technique was used. Quantitative data was obtained. The
study groups consisted of 66 subjects divided into two equal groups of smokers S and non- smokers M, of ages between
15yrs-60yrs. Cellular diameter CD, nuclear diameter ND and nuclear to cytoplasmic ratio N/C ratio was assessed in buccal
mucosal smears taken from clinically normal mucosa of smokers and normal subjects using exfoliative cytology. SPSS
version 17.0 was used for data entry and statistical analysis. ANOVA and post-hoc tuckey were used for statistical analysis.
Results: The mean cellular dia meter of smokers and non-smokers was 54.41± 3.30gm and 43.81±2.01gm respectively. The
mean nuclear diameter of smokers and non-smokers was 12.68± 0.90gm and 9.97± 0.80gm respectively. And the mean
N/C ratio of group smokers and non-smokers was 1:4.43±0.38 and 1:4.42±0.41 respectively. The ONE WAY ANOVA test
showed significant results (p=O.OOO) for cellular diameter CD, nuclear diameter ND and N/C ratio both, while post hoc
tukey test gave highly significant results for CD and N/C ratio i.e p=O.OOO.
Conclusion: Exfoliative cytology and cytomorphometry can help in the early detection of cellular changes as these
techniques are easy, non-invasive and reproducible. Moreover, there is significant cause effect relationship between
smoking and variables as nuclear diameter ND and N/C ratio.
Rabia Masood, Rozinah Jaffar, Nadia Zaib, Ali Raza, Naila Umer. (2015) Oral Cytomorphometry of Smokers and Non Smokers, Journal of Islamic International Medical College, Volume-10, Issue-3.
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