Abstract
BACKGROUND: Helicobacter Pylori is a common infection highly prevalent globally causing
chronic gastritis, duodenal ulcer and gastric carcinoma. It is observed clinically that patients
who underwent therapy for eradication of H Pylori developed weight gain.
Objective of this study was to evaluate the association between weight gain and eradication of
H pylori infection.
METHOD: For this observational cross sectional study, 137 patients were studied after confirmation of diagnosis of H pylori. Base line data at the beginning of the study and comparison
between pre- treatment and post treatment outcomes were assessed after 3 months of follow
up.
RESULT: After eradication therapy, a difference in body weight was evident from pre-treatment
mean body weight of 61.7±12.3 kg to 62.5±11.2 Kg (P=0.011). An increase in BMI was recorded
from pretreatment BMI of 23.24 ±2.1Kg/m2 to 26.4±3.8 Kg/m2 (P=0.028). The assessment of symptoms was performed by applying Mann-Whitney U test of significance; score of symptoms
showed a decline in intensity after eradication therapy. Mean score of dyspepsia decreased
from 2.65 to 1.02 with a P value of 0.024, mean score of epigastric pain from 2.73 to 1.14
(P=0.041), mean upper abdomen fullness from 2.49 to 0.35(P=0.021). A decrease in heart burn
was noted 3.46 vs 0.92 (P=0.003) and loss of appetite was less severe; 2.89 vs 0.58 (P=0.011)
CONCLUSION: The eradication of H Pylori, after 3 months of treatment, is associated with mild
weight gain.
Mohammad Khalid Shaikh, Samiullah Shaikh, Jawed Samo, Ghulam Hussain Baloch, Muzzafar Shaikh, Farhana Mangrio. (2016) Association between Helicobacter Pylori Eradication and Weight Gain, Journal of Liaquat University of Medical and Health Sciences, Volume-15, Issue-1.
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