Abstract
BACKGROUND: In addition to its effect on the bones, vitamin D has a myriad of extra skeletal
roles. It has been implicated both in the development of type 1 and type 2 diabetes mellitus as
well as glycemic control. There is widespread vitamin D deficiency in Pakistan. Incidence of
diabetes mellitus is also increasing exponentially. There is a need to define the relationship
between 25hydroxy vitamin D and type 2 diabetes.
OBJECTIVE: The purpose of this study was to determine the prevalence of hypovitaminosis D
in type 2 diabetes and its association with the level of control of diabetes mellitus.
MATERIALS AND METHODS: This descriptive cross sectional study was conducted at the
Department of Internal Medicine, Sir Syed College of Medical Sciences and Hospital Karachi
from January to June 2015. Total 168 adult cases of Male and Females patients having type 2
Diabetes Mellitus were included. After taking the informed consent; demographic details, duration of diabetes, and modes of treatment for diabetes were recorded. The glycemic profile and
levels of vitamin D were assessed. Glycemic control was categorized as satisfactory and unsatisfactory glycemic control while vitamin D levels were categorized as sufficient, insufficient and
deficient. The data was analyzed on SPSS version 20.0. Mean ±SD was computed for quantitative variables. Frequency and percentages was computed for categorical variables. Relationship
of the glycemic control with vitamin D was computed through Chi-square test. P-value of <0.05
was considered significant.
RESULTS: Among 168 cases (45.2% males and 54.8% females), mean age was 46.7±12 years
and mean duration of diabetes 7±4.4 years. Mean HbA1c was 8.3 ±2.28 with 62% patients having
unsatisfactory glycemic control. A large proportion of the patients had vitamin D deficiency
(80.8%). Deficiency of vitamin D was significantly associated with both fasting and random
blood glucose levels as well as HbA1c.
CONCLUSION: A large majority of patients with type 2 diabetes mellitus have vitamin D
deficiency and the poorly controlled diabetes mellitus is significantly associated with vitamin D
deficiency
Farhat Bashir, Zia Ullah Khan, Sobia Qureshi, Naresh Kumar Seetlani, Zaman Sheikh. (2016) Prevalence of Hypovitaminosis D in Type 2 Diabetes Mellitus and its Relationship with Glycemic Control, Journal of Liaquat University of Medical and Health Sciences, Volume-15, Issue-2.
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