Abstract
OBJECTIVE: To evaluate serum cobalamin with special reference to dyslipidemia in type 2 Diabetic subjects.
STUDY DESIGN: Observational study
PLACE AND DURATION: Department of Medicine, Isra University Hospital and Consultant Clinics Hyderabad, Sindh from January 2014 to July 2014.
METHODOLOGY: A sample of 107 type 2 diabetic subjects was selected according to inclusion
and exclusion criteria. Cobalamin was measured on Roche Cobas e411 chemistry analyzer and
blood lipoproteins by standard laboratory methods. Data was analyzed by SPSS) version 21.0
using appropriate statistical test. P-value of ≤ 0.05 was considered significant.
RESULTS: Cobalamin deficiency was noted in 51 (47.6%) of diabetics which has associated with
dyslipidemia. Mean ± SD of serum cobalamin in normal and reduced serum cobalamin groups
were noted as 355±29.5 and 183±17.5 pg/ml respectively (p=0.0001). Triglycerides, total cholesterol, HDLc, LDLc and VLDLc differed significantly in the normal and reduced cobalamin subjects. Lipoprotein sub fractions showed a negative correlation with serum cobalamin.
CONCLUSION: Cobalamin deficiency is common in type 2 diabetics associated with dyslipidemia.
Haji Khan Khoharo, Iqbal Ahmed Memon, Shuja Anver Kazi, Fatima Qureshi. (2015) Serum Cobalamin and Dyslipidemia in Type 2 Diabetics, Journal of Liaquat University of Medical and Health Sciences, Volume-14, Issue-1.
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