Abstract
OBJECTIVE: Type 2 Diabetes mellitus is more common among chronic hepatitis C patients.
Various risk factors that predisposes chronic hepatitis C patients’ to develop Type 2 Diabetes,
includes age, sex, BMI and positive family history of diabetes mellitus. The objective of present
study is to determine the frequency of Type 2 Diabetes mellitus in chronic hepatitis C virus infection and to compare the clinico-demographic features of hepatitis C cases with or without
diabetes mellitus.
METHODS: This cross sectional study was done in medical wards of Liaquat University Hospital
Hyderabad / Jamshoro from August 15, 2010 to February 15, 2011.Hundred consecutive patients
of chronic hepatitis C virus infection were enrolled after getting informed consent. Baseline patient’s data was collected with the help of a self-administered questionnaire which includes patient’s history and physical examination. Patients were especially asked about family history of
Diabetes mellitus and their body mass index (BMI) and blood pressure were recorded. Blood
samples were drawn after twelve hours of fasting for fasting blood sugar and after two hours of
taking meal for post prandial blood sugar. Liver function test, ultrasound abdomen and serological tests for hepatitis such as hepatitis B surface antigen (HBsAg) and anti hepatitis C antibody (antiHCV) were done in every patient. Patients with Type 1 Diabetes mellitus and those
having positive results for both HBsAg and anti HCV antibody simultaneously were not included in the study. The data was analyzed by SPSS (statistical package for social science) version 10.0. For statistical data analysis, Chi square test was applied. A p value of ˂ 0.05 was considered as statistically significant.
RESULTS: Hundred patients of chronic hepatitis C were included in the study. Sixty were males
(60%) and forty (40%) were females. The age range of patients was 35-74 years and the mean
age was 47.25± 11.02 (SD). Out of hundred patients, twenty seven (27%)had positive family history of diabetes mellitus and twenty eight (28%) had diabetes mellitus themselves. The BMI
range of patients was 21-37 kg/m2 and the mean BMI was 26.03kg/m2 ± 4.30 (SD). Correlation of
age (p = 0.001), BMI (p = 0.009) and family history of diabetes mellitus(p = 0.001)with the frequency of type 2 Diabetes mellitus in HCV +ve patients was statistically significant while comparison of gender with T2DM in HCV patient was not statistically significant (p = 0.413).
CONCLUSION: Type 2 Diabetes mellitus is more common among patients with chronic hepatitis
C than those without hepatitis C. Increasing age, positive family history of diabetes mellitus and
raised BMI are the risk factors for its development.
Aslam Ghouri, Santosh Kumar, Sajjad Ahmed Khan, Mohammad Hanif Ghani, Soniha Aslam, Asadullah. (2014) Frequency of Type 2 Diabetes Mellitus in Patients with Chronic Hepatitis C Virus Infection, Journal of Liaquat University of Medical and Health Sciences, Volume-13, Issue-2.
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