Abstract
Hypothyroidism may present with various systemic manifestations including hypothyroid
myopathy as a recognized feature. It is characterized by muscle weakness, pain, stiffness, and
cramps along with elevated muscle enzymes and thyroid stimulating hormone levels.One of the
rare presentations of hypothyroidism is Hoffman Syndrome characterized by myopathy along
with muscle pseudohypertrophy and raised muscle enzymes. We report a case of Hoffman syndrome that showed significant clinical and biochemical response to thyroid hormone replacement. This case report highlights the clinical features, diagnostic approach and management of
Hoffman syndrome. This signifies that early diagnosis and appropriate management improves
outcome and prognosis. There have been few such cases reported worldwide and we report
this rare case from Pakistan.
Nadia Shams, Furquana Niaz , M. H. Osmani. (2013) Hoffman Syndrome; Rare Presentation of Hypothyroidism, Journal of Liaquat University of Medical and Health Sciences, Volume-12, Issue-3.
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