Abstract
Uninhibited proliferation and abnormal cell cycle regulation are the hallmarks of cancer. The main role of
cyclin dependent kinases is to regulate the cell cycle and cell proliferation. These protein kinases are
frequently down regulated or up regulated in various cancers. Two CDK family members, CDK 11 and 12,
have contradicting views about their roles in different cancers. For example, one study suggests that the
CDK 11 isoforms, p58, inhibits growth of breast cancer whereas, the CDK 11 isoform, p110, is highly expressed
in breast tumor. Studies regarding CDK 12 show variation of opinion towards different parts of the body,
however there is a consensus that upregulation of cdk12 increases the risk of breast cancer. Hence, CDK 11
and CDK 12 need to be analyzed to confirm their mechanism and their role regarding therapeutics, prognostic value, and ethnicity in cancer. This article gives an outline on both CDKs of information known up to
date from Medline, PubMed, Google Scholar and Web of Science search engines, which were explored
and thirty relevant researches were finalized.
Danish Mohammad, Rida Tafveez, Zain Jawed Abubaker, Shamim Mushtaq. (2020) Biological Role of CDK 11 and 12 in Cell Cycle and its Function in Tumorigenesis, The Pakistan Journal of Medicine and Dentistry, Volume 9, Issue-3.
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