Abstract
Background: Thyroxine has shown beneficial effects on intelligence, learning, and memory process in
patients of congenital hypothyroidism. Minocycline has been used in clinical practice for various indications
and reported to have anti-thyroid effects. This study was specifically designed to observe the role of thyroxine on minocycline induced damage to thyroid gland.
Methods: This experimental study was undertaken at Anatomy department of BMSI, JPMC, Karachi, for eight
weeks, from October to November 2019. Thirty adult (10-12 months) male guinea pigs, weighing from
450-650 gm were obtained and divided into 3 groups. Group A served as control, group B was given Minocycline 0.02mg/gram/day once daily and group C was administered Minocycline in similar amount as group
B along with thyroxine 0.5µg/gram/day for the same duration. Dosing was continued for 8 weeks, at the
completion of which all the animals were sacrificed. Thyroid gland was processed and tissue sections were
stained with Haematoxylin and Eosin for morphology.
Results: The absolute weight of thyroid gland was significantly increased (p<0.001) in minocycline treated
group B animals compared to the control animals, whereas substantial decrease (p<0.01) in absolute weight
of thyroid gland was witnessed in group C in comparison to group B animals. The follicular cells showed
hypertrophy and shrinkage of colloid in the thyroid follicles. These changes were prevented when animals
were co-administered with thyroxine and minocycline in Group C.
Conclusion: Concomitant administration of thyroxine with the antimicrobial drug minocycline showed
protective effects of thyroxine on Minocycline induced damage to thyroid gland of animals.
Naheed Gohar, Aisha Qamar, Asma Siddiqui, Tahira Assad, Sahal Salman. (2020) Protective Effect of Thyroxine on Minocycline Induced Thyroid Gland Damage, The Pakistan Journal of Medicine and Dentistry, Volume 9, Issue-2.
-
Views
529 -
Downloads
50
Article Details
Volume
Issue
Type
Language
