Abstract
Background: Prostatic diseases are a leading cause of frequent urinary complaints in elderly males. The most
common diseases include prostatitis, benign prostatic hyperplasia, and prostate cancer. This study aimed to
determine the frequency of the prostatic diseases, their trend over the years, and the association of age and
diagnosis.
Methods: A retrospective descriptive study was conducted in Basic Medical Sciences Institute (BMSI) at
Jinnah Postgraduate Medical Centre, Karachi. Data was collected from the histopathological files and all
the cases diagnosed from 2014 to 2018 were included. Statistical analysis was done using SPSS with 95%
confidence interval and p-value of ≤ 0.05 was considered significant. The Chi-square test was applied to find
the association with age and year of diagnosis.
Results: Total 163 prostate cases were documented from 2014 to 2018, out of which 98 (60.1%) were of
benign prostatic hyperplasia, which was most commonly diagnosed in men aged, 61-70. Prostatic
adenocarcinomas having Gleason scores 8-10 were frequent and commonly seen in men aged 51-60 years.
An increasing trend (p-value=0.053) was observed in the diagnosis of these prostatic diseases within these
five years.
Conclusion: Benign prostatic hyperplasia is the most frequently (p-value=0.140) diagnosed prostatic disease
in men, followed by adenocarcinoma and prostatitis. Advanced stage prostatic adenocarcinoma was
diagnosed more frequently 17(10.4%) and at an earlier age. There is an increase in the number
(p-value=0.053) of cases of prostatic diseases diagnosed each year. National-level studies and health
policies are needed to facilitate early diagnosis and treatment.
Asma Shabbir, Umaima Tariq Khan, Diya Nisar, Parversh Kumar Rath, Cheena Kumari, Talat Zehra, Syed Mehmood Hasan. (2021) Frequency and Trends of Prostatic Diseases in a Subset of Karachi Population: A Retrospective Study, The Pakistan Journal of Medicine and Dentistry, Volume 10, Issue-1.
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