Abstract
Cardiovascular disease (CVD), the leading cause of mortality around the world, among many risk factors
has but some are modifiable one of which is lifestyle. The key element in the healthy lifestyle is diet that
boosts cardiovascular health, especially few key vitamins which have been found to help the heart and
blood vessels working properly. Vitamins, especially those with antioxidant potency, may have a role in the
prevention of and therapy for CVD. Antioxidant vitamins such as vitamin C, vitamin E, and carotenoids are
able to decrease the rate of oxidative stress, which may have a principal role in the pathogenesis of atherosclerosis and CVD. Vitamin D also contributes to the maintenance of cardiovascular health and can induce
cardio protective effects. Although most of the randomized controlled trials on vitamins failed to show the
benefit of vitamin supplementation for cardiovascular outcomes, a number of observational and cohort
studies, meta-analyses, and stratified analyses of large vitamin trials appeared to show an effect in some
aspects of cardiovascular prevention. Moreover, many of the vitamin trials for secondary prevention are
biased by use of vitamins and drugs effective for cardiovascular prevention; therefore, the conclusions
drawn from them supporting the effectiveness of vitamin substitution for the prevention of CVD may be inappropriate. This review summarizes the available data suggesting the role of few vitamins in cardiovascular
health and in the primary prevention of CVD; also, examining the use of new concepts and new study
designs to establish the effectiveness of vitamin supplementation in the therapy for and prevention of CVD.
Hafiz Syed Mohammad Osama Jafri, Saeeda Baig, Sabra Siraj. (2018) Role Of Vitamins In Cardiovascular System –A Review, The Pakistan Journal of Medicine and Dentistry, Volume-7, Issue-1.
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