Abstract
Background: Diabetes mellitus is a growing menace and the cost of treatment and debilitation is high especially in poor
societies. Hyperglycemia in diabetes is associated with deranged lipid profile. Various parts of plants and herbs have been
indigenously used around the world for treatment of diabetes mellitus. Root, bark, leaves and latex of Calotropis procerahave been experimentally studied for their antidiabetic effect. This study was undertaken to explore the antidiabetic and
antidyslipidemic effect of the flowers of Calotropis procera.
Methods: Diabetes was induced by streptozotocin. Calotropis procera flowers aqueous extract (CFEX) was given orally
in doses of 10,20,30,40 and 50 mg/kg body weight. Serum levels of total cholesterol, triglycerides, HDL and LDL were
measured at the beginning of experiment and at intervals of 1 day, 1 week, 2 weeks and 3 weeks and compared with
those in positive controls treated with glibenclamide and untreated negative control animals.
Results: Weight loss in CFEX-treated animals was not significantly different from positive control group. Decrease in serum
glucose levels, comparable to positive controls, was observed in animals treated with CFEX 20,30,40 and 50 mg/kg body
weight. The TC, TG and LDL significantly decreased while a significant increase in HDL was seen.
Conclusion: Calotropis procera flowers extract has shown antihyperglycemic and antidyslipidemic effects in experimental diabetic rats and may have the potential of a potent antidiabetic agent.
Mohammad Afzal Khan. (2016) Antihyperglycemic And Antidyslipidemic Effect Of Calotropis Flowers In Experimental Diabetic Rats, The Pakistan Journal of Medicine and Dentistry, Volume-5, Issue-1.
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