Abstract
Background:
Cotinine is a major metabolite of nicotine and retains for a substantial time in different body fluids. It is considered as a passive smoke exposure marker. Studies on different biochemical markers of tobacco smoke exposure are lacking in Pakistan and serum continine levels in nonsmokers provide a comprehensive measure of passive smoking from all sources in the last two to three days.
Objective:
To compare the frequency of serum cotinine detection in smokers, passive smokers and never smokers.
Methods:
Serum cotinine was analyzed on 135 self reported smokers, never smokers and passive smokers by 17-A gas chromatograph with flame ionization detector (FID) equipped with Supelco SPB-5 fused silica capillary column attached with Class GC 10 Software. Association between the qualitative variables (cotinine present/absent) between groups (smoker, never smoker and passive smoker) was taken out using Pearson chi-square test. The mean difference for serum cotinine between the groups (smoker, never smoker and passive smoker) was evaluated by using kruskal wallis test. P-value less than 0.05 was taken as significant.
Results:
Serum cotinine was detectable in 72.1% of passive smokers which was a significantly higher proportion than smokers and never smokers (p< 0.001).
Conclusion:
Cotinine was detectable in the serum of smokers and passive smokers. Passive smoking may contribute to increased serum cotinine levels. Large sample size may be required to establish it as a marker for environmental tobacco smoke exposure marker and for validation of smoking status.
Zil-a-Rubab, Mohammad Ata-ur-Rehman, Saeeda Baig. (2014) Relation of Serum Cotinine with Passive Smoking, The Pakistan Journal of Medicine and Dentistry, Volume-3, Issue-3.
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