Abstract
Objectives: To evaluate the effect of heart failure with reduced ejection
fraction (HFrEF) on retinal nerve fiber layer (RNFL) thickness.
Methodology: The study included patients who were being followed at
Kartal Kosuyolu High Speciality Training and Research Hospital for HFrEF
and were referred to the Eye Clinic of the Dr. Lütfi Kırdar Kartal Training
and Research Hospital, Istanbul, Turkey between 2017-2019. Study
participants were divided into two groups, one comprising HFrEF patients
and a control group of patients without HF. Each patient underwent a
routine ophthalmologic examination including best corrected visual acuity
evaluation, intraocular pressure measurement, slit-lamp biomicroscopy
and fundus examination. The RNFL of each patient was measured using
spectral domain OCT.
Results: A total of eyes of 37 HFrEF patients and 38 controls were
evaluated. Superior RNFL thickness was 113.71±17.08 μm in the HFrEF
group and 126.22 ± 13.68 μm in the control group (p=0.001). Inferior RNFL
thickness was 117.88 ± 14.5 μm in the HFrEF group and 131.69 ± 12.93
μm in the control group (p<0.001). Average RNFL thickness in the HFrEF
and control groups was 92.32 ± 10.22 μm and 103.31 ± 8.14 μm,
respectively. There were significant differences between the study groups
in all five parameters.
Conclusion: In this study, RNLF thinning occurs in HFrEF compared to
the control group that may be useful for demonstrate tissue perfusion
deficiency in HFrEF.
Muhammed Nurullah Bulut, Mert Evlice. (2021) Peripapillary Retinal Nerve Fiber Alterations In Heart Failure With Reduced Ejection Fraction, Pakistan Heart Journal, Volume-54, Issue-1.
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