Abstract
Background: Sickle cell disease (SCD) is an autosomal recessive disease caused by a single gene
mutation, leading to sickle-shaped red blood cells, causing many clinical complications. Resulting
complications may affect the growth of the SCD patients that is a strong measure of severity of disease
and helps in disease management strategies in any area. Eastern province of Saudi Arabia has one of the
highest SCD incidences. Nevertheless, no studies have been previously carried out of about clinical outcome of
SCD in Al-Ahsa area of eastern province. Therefore, this study was conducted to find out the impact of SCD
children at king Abdulaziz Hospital Al-Ahsa.
Methods: All pediatric SCD patients were included in the study. Patient data was taken from hospital information
system and analyzed using SPSS version 27.
Results: A total of 53 patients were studied. The male to female ratio was 1.4:1 and mean age was 3.3 years
(range: 1-9). Eighteen (34%) did not present with sickle cell crisis possibly due to ameliorating effects of high
HbF and G6PD deficiency. Although growth parameters of SCD patients were not statistically different from
international standards, there was significant difference between weight of SCD patients in recurrent sickle cell
crisis group and non-crisis sickle cell (NC-SC) group at diagnosis and after clinical interventions (p= 0.04 and
0.03, respectively) that included hydroxyurea. The corrected reticulocyte (at diagnosis and after clinical
intervention) and WBC counts were statistically significant between hydroxyurea and non-hydroxyurea groups
(p-value < 0.05).
Conclusions: Overall, one-third of SCD patients in Al-Ahsa region have mild disease and hydroxyurea can
minimize the SCD severity through lowering corrected reticulocyte and WBC counts. Exact mechanisms of mild
SCD and hydroxyurea in minimizing disease severity are needed to be elucidated.
Nawaf Alanazi, Shahad Alabdullatif, Maryam Albahrani, Malak Aljamaan, Fatimah Alsayegh, Aysha Bhalli, Khaled Aljarrah, Zafar Iqbal. (2020-2021) Impact of Sickle Cell Anemia on children growth and clinical parameters in Al-Ahsa region of Saudi Arabia, Advancements in Life Sciences, Volume-8, Issue-2.
-
Views
857 -
Downloads
72
Article Details
Journal
Volume
Issue
Type
Language
Received At
Accepted At
