Abstract
Background: Dengue viral infection is an important and rapidly spreading mosquito borne infection of humans
worldwide.
Objective: To evaluate the clinicopathological features of patients with dengue fever.
Methodology: A descriptive cross sectional study was conducted to evaluate the clinicopathological features of
patients with dengue viral infection in Pakistan Atomic Energy Commission General Hospital, Islamabad. A total
of 62 patients of Dengue infection were followed and documented in this study. A detailed clinical history,
physical examination, and investigations were noted using a structured Performa. Tests included complete blood
count (CBC), serum Aminotransferases including Alanine aminotransferase (ALT), Aspartate aminotransferase
(AST), and dengue serology.
Results: Out of 62 patients with diagnosis of Dengue viral infection through Dengue serology test, 59 cases
fulfilled the WHO diagnostic criteria of probable Dengue fever and 3 cases fulfilled the diagnostic criteria of
Dengue Hemorrhagic Fever (DHF), including Dengue Shock Syndrome (DSS). Male to female ratio was 5׃1 and
median age of the patients was 34 years (ranged from 4 to 70 years). Fever was the main symptom (100% of
cases), followed by generalized body aches and pains (in 73% of cases), at the time of presentation. Mean
hemoglobin level was 14 ± 1.8 gm/dl, while total leukocyte count (TLC) was <4000/µl in 84%, and platelets
were <150,000/µl in 100% of the cases. Serum aminotransferases (AST, ALT) were deranged in 70% of the cases.
Conclusion: This study shows slight difference in clinicopathological features of patients with dengue infection
compared to those in other parts of the world, which can help the clinicians in early detection of dengue infection
and on those basis further workup and management can be planned.
Aliya Batool, Bushra Anwar, Amina Rasul, Sadaf Khalid, Naghmi Asif, Hijab Shah. (2020) Clinicopathological Features of Dengue Fever–a Single Center Study, International Journal of Pathology, Volume-18, Issue-2.
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