Abstract
Objective: To determine the sensitivity, specificity, positive predictive value and negative predictive value of Immuno-chromatographic test (ICT) in patients with visceral Leishmaniasis simultaneously diagnosed by examination of bone marrow aspirate, a gold standard test. Methodology: This descriptive cross sectional study was conducted at a tertiary care hospital from February 2016 to February 2020 on 55 consecutive patients from endemic areas with clinical suspicion of visceral Leishmaniasis, coming for bone marrow examination. A nonrandom convenience sampling technique after informed written consent. Bone marrow was aspirated from each patient under local anesthesia, followed by 3 ml venous blood sample. The ICT was done by trained personal that was kept blind of the prior diagnosis of visceral Leishmaniasis. The data obtained were analyzed by SPSS-24. Results: Age group <5 years was commonest among affected with male predominance, followed by 5-10 years & >10 years. The ICT was positive in 49/55 (87.27%) and negative in 6/55 (12.73%). Bone marrow examination revealed LD bodies in 50/55 (90.91%) and no LD bodies in 05(9.09%) patients. Conclusion: ICT had high sensitivity and positive predictive value, but comparatively low specificity and negative predictive value for visceral Leishmaniasis. It should not be used as a single confirmatory test for visceral leishmaniasis.

Jamila Farid, Muhammad Idris, Nasreen Gul. (2021) Diagnostic accuracy of rapid immunochromatographic test in the diagnosis of visceral leishmaniasis, taking bone marrow as gold standard, , Volume-46, Issue-2.
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