Abstract
Objective: To assess the disruption in the number of kupffer cells induced by isoniazid and role of propolis extract in male albino mice. Methodology: This randomized Control Trial (RCT) was executed on healthy male albino mice, which were kept in animal house of University of Health Sciences, Lahore in 2012. Group I; received normal diet and fresh water orally. Group II; received normal diet, fresh water and isoniazid 100mg/kg body weight orally for 30 days. Group III, IV and V received 150 mg/kg body weight of propolis extract orally for 10 days, 20 and 30 days, respectively and isoniazid 100mg/kg b.w. orally for next 30 days. Kupffer cells were inclusively enumerated in H & E stained sections after calibrating ocular reticule with the help of light microscope. Results: Group I showed the normal number of kupffer cells. Group II showed that remarkable kupffer cells hyperplasia which was significantly reduced in Group IV and V with increasing duration of administration of same dose of propolis. Conclusion: Isoniazid is a hepatotoxic agent which is shown by kupffer cells hyperplasia in liver and Propolis decreased number of kupffer cells which showed its hepatoprotectivity.

Farhat Humayun, Tabish Humayun, Nida Gulzar Zeb. (2021) Hepatoprotective effect of propolis extracts against kupffer cells hyperplasia by isoniazid in albino mice, , Volume-46, Issue-2.
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