Abstract
Objective: To correlate the plasma omentin-1 with the presence of atrial fibrillation in patients with coronary artery disease (CAD).
Methodology: This cross-sectional study was performed at cardiac unit of Civil Hospital Karachi, Pakistan, from June 2016 to March 2017. A total of 195 patients of coronary artery disease, and 150 without atrial fibrillation (AF) were included in the study. Diagnosis of AF was made on the basis of electro-cardio-graph. Plasma omentin-1 levels were determined by enzyme linked immuno- sorbent assay. Data were analyzed by using SPSS version 16.
Results: Out of the 195 patients of AF (37 with permanent, 63 with persistent and 76 with paroxysmal AF), it was found that CAD patients with AF had reduced plasma omentin-1 levels (59.2±9.10 vs. 96.9±11.7, p<0.01). In addition, subgroup with permanent AF was found with significantly lessened omentin-1 as compared to other subgroups (37.4±8.10, 63.3±10.0, and 76.9±12.7, p<0.01). Both simple and multivariable regression analysis revealed momentous association of plasma omentin-1 with less chance of developing AF.
Conclusion: The risk of AF increases with lower plasma omentin-1 concentrations in coronary artery disease patients.
