Abstract
Objective: To find the bacterial isolates causing neonatal sepsis and their antibiotic susceptibility patterns. Methodology: This cross-sectional observational study was done at Department of Pediatrics, Ayub Teaching Hospital, Abbottabad, from June to December 2019. A total of 84 confirmed blood culture positive cases of both genders, aged <28 days and admitted with neonatal sepsis were enrolled. Identified organisms were tested against commonly used antibiotics for susceptibility patterns. Results: Out of a total of 84 neonates, 54 (64.3%) were boys and 30 (35.7%) girls. Most (50; 59.5%) had gram positive bacterial isolates. Most commonly involved gram positive isolates were Staphylococcus aureus (23; 46.0%) while Klebsiella pneumoniae was the commonest gram negative isolate, found in 13 (38.2%) cases. Overall, causative agent isolates showed highest antimicrobial sensitivity patterns for Linezolid (91.5%), Amikacin (90.8%), Clindamycin (89.5%), Piperacillin Tazobactum (84.8%) and Vancomycin (80.6%) while Amoxicillin (80.8%), Ampicillin (79.7%), Cefotaxime (70.7%) and Ceftriaxone (69.9%) had highest rates of resistance. Conclusion: Staphylococcus aureus, Staplhylococcus epidermidis and Klebsiella pneumonia were the commonest causative agent for neonatal sepsis. Routinely used empirical antibiotics like Cefotaxime, Ceftriaxone, Ampicillin and Amoxicillin had high rates of resistance.

Muhammad Adnan, Amna Khan, Ammara Khalid, Sajjad Ahmad Khan, Ifnan Shamraiz, Khyal Muhammad. (2020) Emerging pattern of bacterial isolates causing neonatal sepsis and their antibiotic susceptibility, , Volume 45, Issue-4.
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