Abstract
Objective: To evaluate the clinical, hormonal and metabolic factors associated with polycystic ovary syndrome (PCOS) among women in tertiary care hospital in Hyderabad, Pakistan.
Methodology: This cross-sectional study was carried out at the Nazeer Hussain Medical Complex, Hyderabad from December 2018 to May 2019. Participants were selected using non-probability purposive sampling technique. Females between 16-40 years with or without history of PCOS and menstrual irregularities like Oligomenorrhea, Polymenorrhea, Amenorrhea, etc. were included in the study. Females on oral-contraceptives >4 weeks, insulin-sensitizing agents or hormonal therapy >2 weeks, history of other disorders (gynecological, thyroid etc.) were excluded. Anthropometric, clinical, hormonal and biochemical parameters were measured for all participants. Chi-square and student t-tests were used to analyze the data using SPSS version 23.
Results: Study has 200 patients with mean age of 29.23±4.12 years. The prevalence of PCOS was 48.5% using Rotterdam criteria. Menstrual irregularities were the most common presenting complaints. BMI, waist circumference, and systolic blood pressure were higher among the PCOS group. The difference between clinical, biochemical and hormonal parameters among PCOS and no-PCOS participants was statistically significant (p<0.05). A positive correlation between increased BMI, increased Luteinizing /Follicle-stimulating hormone ratio and serum testosterone was observed.
Conclusion: Women having PCOS were mostly obese with BMI>30Kg/m2. Irrespective of their weights, these patients exhibits hormonal as well as metabolic abnormalities and menstrual irregularities.
