Abstract
Objective: To estimate the serum Testosterone in
obese and Diabetes Mellitus Type-II Obese
males.
Methodology: This cross-sectional study was
conducted in the Institute of Biotechnology and
Genetic Engineering, University of Sindh,
Jamshoro, with the collaboration of Department of
Medicine, Liaquat Hospital Jamshoro from April to
September 2018. A total 150 males were included
in this study and divided into three groupwith 50
patients in each group. Group A patients were
healthy normal males, Group B were obese males
(BMI>25) and Group C were obese Type IIdiabetic
males ages 20-70 years. Fasting blood
sugar (FBS), Random blood sugar (RBS), HbA1c,
serum Insulin and serum Testosterone levels were
determined. The ANOVA test was applied for the
analysis of continuous variables.
Results: We found significant results of FBS,
RBS and HbA1c in T2DM patients as compared to
controls (p<0.001). Serum Insulin and serum
testosterone was lower significantly in group C as
compared to control group. The BMI of group B
and C was higher as compared to control group
(p<0.001). Waist/hip ratio in obese and T2 diabetic
males was higher as compared to control
(p<0.001).
Conclusion: Obesity male patients with Type-II
Diabetes mellitus had lower levels of serum
testosterone. Early screening and weight
reduction by exercise will be helpful in prevention
of T2DM in males and enhance their quality of life
by maintaining their testosterone level. (Rawal
Med J 202;45:42-45).
