• Si Ra Bang

• Hyo jin Kim

• Eun Jin Ahn

• Hey Ran Choi

• Kyung Woo Kim

• Myoung Jin Ko

• Eunsu Kang

• Yun Jung Sung

• Yong il Ji

• Jae-Wook Jung

Abstract

Objective: To evaluate the efficacy of palonosetron and ramosetron for the prevention of PONV in high risk patients undergoing gynecologic laparoscopic surgery. Methodology: In this randomized, double-blind, placebo-controlled study, a total of 87 female patients who were undergoing elective gynecologic laparoscopic surgery under general anesthesia were included. Patients were randomly divided into the following three groups: palonosetron group (0.075 mg i.v. n=29), ramosetron group (0.3 mg i.v. n=29) and control group (0.9 % normal saline i.v. n=29). The occurrence of nausea and vomiting and the severity of nausea were evaluated using visual analogue scale. Administration of rescue anti-emetics was monitored during 48 hours after the end of surgery. Results: The incidence of nausea was significantly lower in the palonosetron and ramosetron groups compared with the control group (34.5% vs 31.0% vs 65.5%, p=0.014) during 2 hours postoperatively, but not during 48 hours postoperatively. There were no significant differences in the incidence of vomiting and overall PONV, and the administration of rescue anti-emetics among the 3 groups. Conclusion: Prophylaxis with ramosetron or palonosetron effectively decreased PONV during the early postoperative period.

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