Abstract
Objective: To determine validity of pyuria in detecting urinary tract infection (UTI) as a quick reliable, first hand diagnostic tool in our population, where cost effectiveness is involved and facilities of culture are not available. Methodology: This prospective cross-sectional study was conducted in KRL hospital, Islamabad, Pakistan over a period of 2 years. Urine samples of all the febrile children with suspected UTI were collected via midstream clean catch technique (in children >3 years) or suprapubic aspiration (in ≤3 years). They were examined microscopically after centrifugation for pus cells. Simultaneously cultures were performed. Specificity, sensitivity, negative and positive predictive values were calculated. Results: Total number of patients was 226. 45.58% were male and 54.42% were females. Mean age was 5.019±3.274 years. Mean weight was 19.575±8.339kg. Pyuria had sensitivity of 68.69%, specificity of 74.80%, PPV of 68% and NPV of 75.40% in detecting UTI. Conclusion: Pyuria can be used as a quick predictor of diagnosing UTI, specially where facilities of culture are not available with acceptable sensitivity and specificity.

Sahira Aaraj, Fareeha Farooqui, Alia Halim, Samara Siddique. (2017) Validity of Pyuria in diagnosis of UTI in febrile pediatric patients keeping urine culture as gold standard, , Volume-42, Issue-4.
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