Abstract
In December2019, a new coronavirus(SARS-CoV-2) was discovered in Wuhan (China)that was rapidly transmittedto many other countries. Henceforth, the World Health Organization (WHO) Emergency Committee declared a global health emergency on January30, 2020. Statistics depictedthe fatality rate as about 1.4%. In this study, a potential antiviral treatment for the SARS-CoV-2 virus using host miRNAs was explored which may slow down the expression of viral genes to suppress viral replication.The miRNAsfrom genome (coronavirus/SARS-CoV-2) were analyzed using various computational approaches.The complete genome sequence was retrieved from NCBI. The result of our study highlighted that hsa-miR-3675-3p (MD19), hsa-miR-363-5p (MD220), hsa-miR-325 (MD306), hsa-miR-2114-5p (MD306), hsa-miR-744-3p (MR186) and hsa-miR-448 (MR186)can be used as an antiviral treatment to quell the replication of SARS-CoV-2virusin humanbeings.Thefindings and observations of our study openednew possibilitiesto explore both the pathogenesis function of miRNAsand for the development of novelantiviral drugs.
Copyright (c) Syed Hassan Abbas, Muhammad Tariq Pervez, Amera Ramzan, Muhammad Xaaceph Khan
Syed Hassan Abbas, Muhammad Tariq Pervez, Amera Ramzan, Muhammad Xaaceph Khan. (2021) In-silico Analysis of Human miRNAs in SARS-CoV-2 Genome, BioScientific Review, Volume 3, Issue 2.
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