• Hafiz Muhammad Arsalan

• Maria Altaf

• Zeemal Seemab Amin

• Muhammad Khalil Ahmad Khan

• Anum Shahzadi

• Hina Mudasser

• Iqra Maqsood

• Nazia Gulshan

• Saira Naseem

Abstract

| Bones determinedly altered through integration body matrix osteoblast, resorption bone via osteoclasts. Rheumatoid arthritis allied with considerable levels pain, tiredness, disability, reduced distinction life. Precise pathogenesis job rheumatoid factor not known, through formation immune complexes engross establishment harmonize. To determine the correlation between Anti-Oxidants and Biochemical status in Rheumatoid Arthritis patients. 60 clinically diagnosed Rheumatoid Arthritis (RA) patients and 50 healthy persons were included in this study. 5 ml Blood was drawn and serum was separated. Anti-Oxidant Biomarkers, Serum micronutrients, serum Electrolyte balance was measured through spectrophotometric procedure. Serum MDA level jump high in patients (14.19) as compared to normal subjects (3.26). Serum Glutathione declined in disease persons (0.56) from healthy subjects (6.39). Serum Micronutrients level was also declined in RA patients as compared to healthy persons and substantial statistically (P=0.000). Serum Nitric Oxide jump high in patients (32.11) than normal persons (15.2). Abnormal concentration of reactive oxygen species can disturb the body’s defense mechanism which cause potential oxidative injury to tissues and lead to cartilage degradation in RA patients

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